Which of the following would contraindicate the use of a partial denture?

The use of a partial denture is contraindicated in cases where periodontal disease threatens the remaining teeth. Periodontal disease can compromise the health and stability of the remaining natural teeth, making them more susceptible to further damage if a partial denture is placed. When the foundation provided by the gums and bone is jeopardized due to periodontal issues, placing a partial denture may not only lead to complications in maintaining the prosthetic but can also exacerbate existing dental problems, leading to tooth loss.

In contrast, replacing several teeth in one quadrant, maintaining good oral hygiene, or a patient's inability to tolerate treatment for a fixed bridge do not necessarily prevent the use of a partial denture. These scenarios can often be managed through careful planning and consideration of the patient's overall dental health, making them less of a concern when determining the suitability for a partial denture.